Accession Number : ADA481652


Title :   Anti-Angiogenic Action of Neutral Endopeptidase


Descriptive Note : Final rept. 1 Nov 2004-31 Oct 2007


Corporate Author : CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK


Personal Author(s) : Nanus, David M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a481652.pdf


Report Date : Nov 2007


Pagination or Media Count : 30


Abstract : Angiogenesis, or the formation of new blood vessels from existing vasculature is an important event in tumor progression. It results from a complex, multistep biochemical cascade that is initiated by the activation of endothelial cells in response to angiogenic factors. In prostate cancers, angiogenic factors are produced by epithelial and stromal cells, and are believed critical to prostate cancer growth and progression. One of the most important of these factors is basic fibroblast growth factor (bFGF), which plays an important role in angiogenesis through the stimulation of endothelial cell proliferation, migration, and protease production in vitro phenomenon. A number of studies both in vitro and in patient specimens suggest that enhanced expression of bFGF contributes to more aggressive prostate cancer. Clearly, a better understanding of the pathways regulating angiogenesis in the prostate and how these pathways change during malignant transformation and prostate cancer progression will assist in developing more effective therapies for patients with prostate cancer.


Descriptors :   *PROSTATE CANCER , *ANGIOGENESIS , FIBROBLASTS , CELLS(BIOLOGY) , ENDOTHELIUM , GROWTH(PHYSIOLOGY) , PEPTIDE HYDROLASES , NEOPLASMS , EPITHELIUM , BLOOD VESSELS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE