Accession Number : ADA481551


Title :   Molecular Imaging of Ovarian Carcinoma Angiogenesis


Descriptive Note : Annual rept. 1 Feb 2006-31 Jan 2007


Corporate Author : STANFORD UNIV CA


Personal Author(s) : Chen, Xiaoyuan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a481551.pdf


Report Date : Mar 2007


Pagination or Media Count : 69


Abstract : This purpose of this proposal is to use high resolution microPET technology to image ovarian cancer integrin expression in vivo. Ovarian cancer is angiogenesis dependent. Integrin , a key player in tumor angiogenesis and metastasis, has been identified as a target for diagnostic and therapeutic interventions for several highly proliferative and metastatic tumor types. The interaction between vitronectin and integrin alphanuBeta3 is essential for ovarian cancer cell survival and invasion. The integrin expression has been identified as a marker of poor prognosis in advanced-stage ovarian cancer. Its role in ovarian cancer development and as treatment target is under-developed. Specific Aim 1: To develop and optimize 18F-labeled RGD peptides for ovarian carcinoma targeting. Specific Aim 2: To test 18F-RGD peptide tracers in ovarian carcinoma models of different tumor integrin alphanuBeta3 expression levels in order to correlate the magnitude of tumor uptake with receptor density. Major Findings: In year 1, we have synthesized a series of multimeric RGD peptides with high integrin alphavbeta3 affinity/specificity and labeled these peptides with F-18 for PET imaging of integrin expression in vivo (Aim 1). We have also established several ovarian cancer models with differentiated integrin levels (Aim 2). Further test of the optimal radiotracer in different ovarian cancer models to correlate the tracer uptake with tumor integrin expression is currently underway (Aim 2).


Descriptors :   *OVARIAN CANCER , *ANGIOGENESIS , *HIGH RESOLUTION , NEOPLASMS , DIAGNOSIS(MEDICINE) , CELLS(BIOLOGY) , INTERVENTION , SENSE ORGANS , METASTASIS , PEPTIDES , PREDICTIONS , SURVIVABILITY , IN VIVO ANALYSIS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE