Accession Number : ADA479746


Title :   UCLA High Speed, High Volume Laboratory Network for Infectious Diseases


Descriptive Note : Final rept. 16 Mar 2007-15 Mar 2008


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Layne, Scott P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a479746.pdf


Report Date : Apr 2008


Pagination or Media Count : 102


Abstract : Background. Government agencies and expert panels have recognized the need for laboratories capable of analyzing tens of thousands of biological samples per day that have hundreds of times more capability than at present. Objectives/Hypothesis. This project aims to develop a new high speed high volume (high-throughput) laboratory capability that will be linked in a network and operated by several premier institutions. The automated networked capability will make us stronger against natural diseases and bioterrorist attacks. Specific Aims. With FY06 (initial year) Congressional appropriations high-throughput bioagent screening and genotyping systems (with quality controls) will be implemented first. These systems will be housed in laboratory space upgraded to BSL3-enhanced (BSL3e) containment that enables the flow of numerous samples containing highly pathologic avian influenza and other select agents (dual-use). With FY07 (available) FY08 (available) and FY 09 (anticipated) Congressional appropriations automated culturing and phenotyping systems will be implemented next. Study Design. Because of current public health and national security threats influenza surveillance and analysis will be the initial focus. Over three years the project will be expanded to include other biothreat agents bacterial and/or viral. Relevance. The combination of high-throughput and automated systems will enable processing of tens of thousands of samples and provide critical laboratory capacity. The overall project will facilitate rapid expansion to multiple networked sites.


Descriptors :   *NETWORKS , *LABORATORIES , *INFECTIOUS DISEASES , AUTOMATION , HIGH RATE , QUALITY CONTROL , PUBLIC HEALTH , INFLUENZA , BIOTERRORISM , SURVEILLANCE , PATHOLOGY , HYPOTHESES , LABORATORY PROCEDURES , REAL TIME , BIOLOGY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE