Accession Number : ADA479315


Title :   Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-abdominal Adhesions, and Arterial Injuries


Descriptive Note : Final rept. 24 Jan 2005-23 Mar 2008


Corporate Author : CHILDREN'S HOSPITAL CORP BOSTON MA


Personal Author(s) : Folkman, Judah


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a479315.pdf


Report Date : 01 Apr 2008


Pagination or Media Count : 89


Abstract : The three goals of this project are: (i) to discover and develop novel drugs which could prevent or reverse the vascular leak syndrome; (ii) to develop angiogenesis inhibitors which would inhibit post-operative abdominal adhesions; and, (iii) to isolate endothelial progenitor cells from blood, capable of being expanded in vitro and applied to vascular grafts. Progress has been made in each category: we have demonstrated that the widely used antibiotic, doxycyline, is a potent inhibitor of VEGF-induced vascular leak, and that a combination of Lodamin and doxycycline have additive effects and inhibit vascular leakage by greater than 80%; we have established that sunitinib likely does prevent intra-abdominal postoperative adhesions in rabbits; and, we have isolated and characterized mesenchymal progenitor cells (MPCs) from human adult bone marrow and from human cord blood; showed expansion potential suitable for tissue engineering and tissue regeneration applications.


Descriptors :   *ADHESION , *CARDIOVASCULAR SYSTEM , *ARTERIES , *ANGIOGENESIS , *STEM CELLS , TISSUES(BIOLOGY) , ENDOTHELIUM , SURGICAL TRANSPLANTATION , WOUNDS AND INJURIES , INHIBITORS , MEDICAL RESEARCH


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE