Accession Number : ADA478982


Title :   Targeting Mucosal Dendritic Cells with Microbial Antigens from Probiotic Lactic Acid Bacteria


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Mohamadzadeh, Mansour ; Duong, Tri ; Hoover, Timothy ; Klaenhammer, Todd


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a478982.pdf


Report Date : 01 Mar 2008


Pagination or Media Count : 13


Abstract : Using vaccines against infectious microbes has been critical to the advancement of medicine. Various vaccine strategies combined with or without adjuvants have been established to eradicate various bacterial and viral pathogens. A new generation of vaccines is being developed using specific strains of the gram-positive lactic acid bacteria, and notably some probiotic lactobacilli. These bacteria have been safely consumed by humans for centuries in fermented foods. Therefore, they can be orally administered, are well-tolerated by recipients, and could easily and economically provided to large populations. In this overview, we focus on mucosal immunity and how its cellular component (s), particularly dendritic cells (DCs), cab be specifically targeted to deliver immunogenic subunits like the protective antigen (PA) from Bacillus anthracis (causative agent of anthrax). An antigen-specific immune response can be elicited by using various strains of Lactobacillus expressing PA. A mucosal, DC targeting approach increases the bio-availability of an immunogen of interest, when delivered orally by Lactobacillus. This provides an efficiently elegant natural strategy and serves a dual function as an immune-stimulating adjuvant in vivo.


Descriptors :   *BACTERIA , *INFECTIOUS DISEASES , *ANTIGENS , *LACTIC ACID , *VACCINES , *PATHOGENIC MICROORGANISMS , FUNCTIONS , STRATEGY , POPULATION , VIRUSES , IMMUNITY , FOOD , LACTOBACILLUS , GRAM POSITIVE BACTERIA , IMMUNOGENS , BACILLUS ANTHRACIS , MUCOUS MEMBRANES , DENDRITIC STRUCTURE , DIRECT CURRENT , IN VIVO ANALYSIS , ANTHRAX , TARGETING , MEDICINE , CELLS , HUMANS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE