Accession Number : ADA474982


Title :   Drug Development and Conservation of Biodiversity in West and Central Africa: Performance of Neurochemical and Radio Receptor Assays of Plant Extracts Drug Discovery for the Central Nervous System


Descriptive Note : Final rept. 1 Sep 1999-31 Aug 2004


Corporate Author : MIAMI UNIV FL


Personal Author(s) : Efange, Simon ; Mash, Deborah C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a474982.pdf


Report Date : 01 Sep 2004


Pagination or Media Count : 34


Abstract : The thrust of the CNS assay panel was to identify plant extracts that display moderate to high affinity for selected molecular targets. Target selection was based identifying active plant extracts that would be useful for one or more neuropsyschiatric disorders. We completed a screen for 102 samples belonging to 43 plants. 41 showed activity at one or more CNS targets. Phytochemical studies have been initiated on several active extracts. A total of 12 plants samples which have tested positive for antiplasmodial activity were collected in bulk quantities for detailed phytochemical investigations into antimalarial and trypanocidal activity.


Descriptors :   *DRUGS , *CENTRAL NERVOUS SYSTEM , NEUROCHEMISTRY , PLANTS(BOTANY) , WEST AFRICA , BIOLOGICAL EXTRACTS


Subject Categories : Biochemistry
      Biology
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE