Accession Number : ADA474717


Title :   A Rat Model of Sytemic Chemotherapy for Breast Cancer to Evaluate and Treat Chemobrain


Descriptive Note : Final rept. 1 Sep 2006-31 Aug 2007


Corporate Author : AUCKLAND UNIV (NEW ZEALAND)


Personal Author(s) : Little, Kevin C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a474717.pdf


Report Date : Sep 2007


Pagination or Media Count : 43


Abstract : The primary objective of this project was to develop an animal model to measure possible cognitive deficits resulting from chemotherapy. We have established a rat model of multidose human-equivalent combination chemotherapy using cyclophosphamide methotrexate and 5-fluorouracil (CMF) that recapitulates the physical symptoms of chemotherapy treatment. We investigated the effects of this regimen on learning and memory as well as on the production and survival of new neurons in the hippocampus (neurogenesis). We found no statistically significant differences between control and CMF animals on any measure of learning or memory nor with respect to neurogenesis.


Descriptors :   *COGNITION , *CHEMOTHERAPY , *BREAST CANCER , RATS , SIGNS AND SYMPTOMS , ANATOMICAL MODELS , METHOTREXATE , NEW ZEALAND , CYCLOPHOSPHAMIDE , HIPPOCAMPUS , DEFICIENCIES , NERVE CELLS


Subject Categories : Psychology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE