Accession Number : ADA474599


Title :   A Novel Strategy for Controlling the Metastatic Phenotype: Targeting the SNAG Repression Domain in the SNAIL Zinc-Finger Protein


Descriptive Note : Final rept. 1 Apr 2002-31 Mar 2006


Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST


Personal Author(s) : Rauscher, III, Frank J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a474599.pdf


Report Date : Jul 2007


Pagination or Media Count : 207


Abstract : BCRP Award has funded fundamental new discoveries into how a key protein involved in the metastatic process of breast cancer functions. We have discovered the following: 1. The SNAIL zinc finger repressor must bind its obligate co-repressor AJUBA, in order to repress e-cadherin and initiate metastasis. 2. The AJUBA interaction is direct and highly specific and this complex can be found at endogenous SNAIL target genes. 3. The binding requires the 20 amino acid SNAG domain of SNAIL and a single LIM domain of AJUBA. This biding forms a well-defined protein-protein interaction, which may be targeted by small molecules to interfere with the metastatic process during breast cancer progression.


Descriptors :   *PROTEINS , *IN VITRO ANALYSIS , *IN VIVO ANALYSIS , *BREAST CANCER , *METASTASIS , FUNCTIONS , TARGETING , FINGERS , SNAILS , GENES , ZINC , TARGETS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE