Accession Number : ADA474594


Title :   Chemistry, Biochemistry, Pharmacology, and Toxicology of CS and Synthesis of Its Novel Analogs


Descriptive Note : Final rept. May 2003-Sep 2004


Corporate Author : SCIENCE APPLICATIONS INTERNATIONAL CORP (SAIC) ABINGDON MD


Personal Author(s) : Munavalli, Shekar ; Rohrbaugh, Dennis K ; Durst, H D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a474594.pdf


Report Date : Oct 2007


Pagination or Media Count : 29


Abstract : Of the potential five groups of less-than-lethal riot control and crowd management agents, three groups, namely co-chloroacetophenones (CN), benzylidene malononitriles (CS-type), and dibenzooxazepines (CR) have found frequent use. Of the three groups, chlorobenzylidene malononitrile (CS) is the most popularly used non-lethal agent in riot control situations and military exercises. With a view to improve its properties and enhance its effectiveness, 15 new CS analogs incorporating fluorine and fluorine-containing groups have been synthesized using microwave irradiation and novel catalysts. The structures and physical properties and mass spectral characterization of this group of highly potent CS-type agents are described herein.


Descriptors :   *SYNTHESIS(CHEMISTRY) , *CS AGENTS , *CHEMICAL ANALOGS , NUCLEAR MAGNETIC RESONANCE , FLUORINE , TOXICOLOGY , NONLETHAL AGENTS , MASS SPECTRA , PHARMACOLOGY , BIOCHEMISTRY


Subject Categories : Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE