Accession Number : ADA473776


Title :   Differential MDR in Breast Cancer Stem Cells


Descriptive Note : Final rept. 30 Jul 2004-20 Apr 2006


Corporate Author : PITTSBURGH UNIV PA


Personal Author(s) : Donnenberg, Albert D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a473776.pdf


Report Date : May 2006


Pagination or Media Count : 44


Abstract : A new paradigm for the proliferation and metastasis of breast cancer posits a rare tumor stem cell with low proliferative index and high self-renewing potential. Like its normal counterpart, the tumorigenic stem cell gives rise to transit-amplifying daughters of high clonogenic potential. These in turn lose clonogenic potential as they follow a dysregulated differentiation program into bulk tumor. The principal hypothesis which this proposal addressed is that the bulk of breast cancer tumor cells arise from rare aberrant stem cells that share functional and phenotypic characteristics with normal tissue stem cells, including high multidrug resistance (MDR) transporter activity. Our studies were based on those of Clarke et al who isolated a rare and highly tumorigenic subset of breast cancer (BrCa) cells on the basis of expression of surface adhesion molecules (CD44+ and CD24low). In this proposal we addressed the hypothesis that these cells (or a subset thereof) have high expression of the MDR transporter ABCG2 and other stem-cell associated markers.


Descriptors :   *BREAST CANCER , *STEM CELLS , DRUG TOLERANCE , METASTASIS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE