Accession Number : ADA473391


Title :   Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles


Descriptive Note : Annual rept. 15 May 2006-14 May 2007


Corporate Author : RICE UNIV HOUSTON TX


Personal Author(s) : Halas, Naomi J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a473391.pdf


Report Date : Jun 2007


Pagination or Media Count : 72


Abstract : This report summarizes the efforts of our team consisting of researchers from Rice University and M. D. Anderson Cancer Center, in the DoD funded CDMRP award towards the development of an integrated nano particle based imaging and therapy of breast cancer. We have made significant progress in our goals to demonstrate enhanced contrast in Optical Coherence Tomography (OCT) imaging tumors and photo thermal ablation using a single multifunctional particle. We have optimized the nanoshell that has a resonance in the near IR physiological water window, and can be used for both optical diagnostic imaging and photo thermal therapy. We have also explored other optical techniques for diagnosing malignant tumors from normal tissue.


Descriptors :   *DIAGNOSIS(MEDICINE) , *THERAPY , *BREAST CANCER , ABLATION , METHODOLOGY , OPTICAL PROPERTIES , NANOTECHNOLOGY , NEAR INFRARED RADIATION , TOMOGRAPHY , PARTICLES , TISSUES(BIOLOGY) , OPTIMIZATION


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE