Accession Number : ADA473365


Title :   Chemoprevention of Breast Cancer by Mimicking the Protective Effect of Early First Birth


Descriptive Note : Annual rept. 2 May 2006-2 May 2007


Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES


Personal Author(s) : Pike, Malcolm C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a473365.pdf


Report Date : Jun 2007


Pagination or Media Count : 37


Abstract : We have successfully shown that in the rat estradiol, estradiol plus progesterone, and beta-HCG is protective against carcinogen-induced mammary tumorigenesis. Progesterone alone was not protective. Also, treatment with perphenazine was partially protective. We have continued to collect normal breast tissue from women undergoing elective reduction mammoplasty. Estrogen receptor and progesterone receptor have been characterized as well as cell proliferation have been characterized in these samples. Two chemoprevention protocols have been developed and are set to begin recruitment in the near future. The first will evaluate the role of high dose progestins on cell proliferation and gene expression profiles in the breast. The second protocol will evaluate the role of various oral contraceptive progestin doses on cell proliferation and gene expression profiles in the breast.


Descriptors :   *BIRTH , *BREAST CANCER , HORMONES , TISSUES(BIOLOGY) , GENES , WOMEN , CHEMOTHERAPY , MAMMARY GLANDS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE