Accession Number : ADA472397


Title :   Gene-Gene and Gene-Environment Interactions in the Etiology of Breast Cancer


Descriptive Note : Final rept. 1 Jun 2002 31 May 2007


Corporate Author : MEHARRY MEDICAL COLL NASHVILLE TN


Personal Author(s) : Marshall, Dana R ; Adegoke, Olufemi J ; Zheng, Wei


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a472397.pdf


Report Date : Jun 2007


Pagination or Media Count : 65


Abstract : The purpose of this proposal is to evaluate gene-gene and gene-environment interactions in the etiology of breast cancer in two ongoing case-control studies, the Shanghai Breast Cancer Study (SBCS) and the Nashville breast health Study (NBHS) and in a proposed case-control study, the Breast Cancer in West Africa Study (BCAWS). An allelic variant of UGT1A1 (allele*28) was identified as a risk factor for postmenopausal breast cancer in Chinese women. A proposal was submitted and funded for the BCAWS study through U54-CA9140801 Adunyah (PI). Samples and surveys acquired from the BCAWS study are currently being analyzed.


Descriptors :   *RISK , *ETIOLOGY , *GENES , *BREAST CANCER , CONTROL , WOMEN , MAMMARY GLANDS , WEST AFRICA , CHINA , INTERACTIONS , HEALTH , CASE STUDIES


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE