Accession Number : ADA471833


Title :   Dietary Seawood and Early Breast Cancer: A Randomized Trial


Descriptive Note : Final rept. 1 May 1998-31 May 2007


Corporate Author : SOUTH CAROLINA UNIV COLUMBIA


Personal Author(s) : Teas, Jane


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a471833.pdf


Report Date : May 2007


Pagination or Media Count : 85


Abstract : The purpose of this research is to investigate whether eating brown seaweed (Undaria pinnatifida) can influence breast cancer risk. Brown seaweeds are popular in Japan, where the incidence of breast cancer is about 1/6 the rate of that reported for American women. In several animal studies of diet and cancer, adding seaweed to the normal diet resulted in longer healthy lives. In particular, we will examine cell surface binding characteristics and protein expression associated with the consumption of dietary seaweeds by women without breast cancer, women with estrogen receptor negative breast cancer, and women with estrogen receptor positive breast cancer. All subjects have completed the study, and all samples have been analyzed for the endpoints definedin the study. Additionally, samples have been analyzed for urokinase and urine as been included in the proteomic study. Papers on iodine content in commercially available seaweeds has been published, as has a review of the health effects of seaweeds and a paper describing the bioavailability of seaweed iodine in brown seaweeds. The analyses of the proteomics data and the flow cytometry data were completed in April and May, and preparation of manuscripts is in process.


Descriptors :   *DIET , *ALGAE , *BREAST CANCER , HEALTH , RANDOM VARIABLES , PROTEINS , JAPAN , ESTROGENS , AQUATIC PLANTS , PREVENTIVE MEDICINE , IODINE , CELLS(BIOLOGY) , WOMEN


Subject Categories : Biology
      Medicine and Medical Research
      Food, Food Service and Nutrition


Distribution Statement : APPROVED FOR PUBLIC RELEASE