Accession Number : ADA471366


Title :   SERDP CU-1129 Biological Assessment for Characterizing Contamination Risk at the Genetic-, Individual-, and Population-Level


Descriptive Note : Final technical rept.


Corporate Author : ENGINEER RESEARCH AND DEVELOPMENT CENTER VICKSBURG MS


Personal Author(s) : Perkins, Ed ; lotufo, Guilherme ; Bridges, Todd S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a471366.pdf


Report Date : 14 Apr 2004


Pagination or Media Count : 141


Abstract : The objective of this project is to develop a suite of technically defensible assays that can be effectively used in regulatory programs to quantify the ecological risk of contaminated sediments at the molecular-, individual-, and population-level. Effects-based assays will be developed which effectively account for contaminant bioavailability while providing an integrated measure of the toxicity of complex mixtures. Dose-response information will be generated for military-relevant contaminants (e.g., TNT, RDX, HMX) by measuring molecular and whole organism responses. Population-level impacts caused by contaminant exposure will be projected using population models developed during this project. A screening approach will be developed to provide cost-effective information about the potential for impacts at the population-level. In developing this screening approach, we will quantify the biological and ecological significance of toxicant effects on gene expression by way of comparison to whole organism toxicity and modeled population-level impacts.


Descriptors :   *CONTAMINANTS , *ECOLOGY , EXPOSURE(GENERAL) , TOXICITY , GENES , MICROORGANISMS , RISK ANALYSIS , SEDIMENTS , RESPONSE(BIOLOGY) , POPULATION , ENVIRONMENTAL IMPACT


Subject Categories : Ecology
      Environmental Health and Safety


Distribution Statement : APPROVED FOR PUBLIC RELEASE