Accession Number : ADA470579


Title :   Breast Tumor Detection and Treatment Using Tarvacin Labeled with Arsenic Radionuclides


Descriptive Note : Annual rept. 1 Apr 2006-31 Mar 2007


Corporate Author : TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS


Personal Author(s) : Mason, Ralph P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a470579.pdf


Report Date : Apr 2007


Pagination or Media Count : 18


Abstract : We will generate a novel approach for detection and therapy of advanced breast cancer based on three fundamentally novel discoveries and concepts. The first critical component exploits a novel antibody, which targets phosphatidylserine (PS), expressed on tumor vasculature. In collaboration with Peregrine Pharmaceuticals, this agent has been chimerized and is being developed for clinical trials as bavituximab (formerly TM). Normally, exclusively resides on the cytosolic leaflet of the plasma membrane, but in tumors PS becomes externalized providing a viable target. The agent not only targets various tumors, but also induces vascular damage and tumor regression with minimal accompanying toxicity. The second component is the identification of diverse arsenic radionuclides suitable for imaging based on PET and radio immunotherapy together with new means of isolating the radionuclides. Importantly, the antibodies can be effectively labeled forming viable products of high specific radiochemical and biological activity. Thirdly, our program brings together pharmacological and radiochemical expertise to facilitate collaboration, progress, and synergy. This project will develop a single agent (bavituximab) for tumor detection, dosimetry, and therapy based on differential properties of arsenic radionuclides, but exploiting a single chemistry.


Descriptors :   *DETECTION , *ARSENIC , *RADIOACTIVE ISOTOPES , *BREAST CANCER , DAMAGE , BIOLOGY , TOXICITY , PLASMAS(PHYSICS) , NEOPLASMS , TARGETS , CARDIOVASCULAR SYSTEM , CLINICAL TRIALS , DOSIMETRY , RADIOCHEMISTRY , MAMMARY GLANDS , BLOOD VESSELS , REGRESSION ANALYSIS , CHEMISTRY , CONFIGURATIONS , VIABILITY , THERAPY , MEMBRANES , ANTIBODIES


Subject Categories : Biochemistry
      Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE