Accession Number : ADA470130


Title :   Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer


Descriptive Note : Final rept. 7 Jan 2005-6 Jan 2007


Corporate Author : BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA


Personal Author(s) : Bubley, Glenn


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a470130.pdf


Report Date : Feb 2007


Pagination or Media Count : 27


Abstract : The P582S C-T and A588T G-A polymorphisms in the Hypoxia-inducible factor-1alpha (HIF-1alpha) gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer (CaP). Methods: We examined the association of these polymorphisms with CaP among 1,072 incident cases and 1,271 controls, and further explored their joint associations with various prediagnostic plasma hormone levels. Results: The A588T polymorphism was too rare to provide meaningful conclusions and the P582S polymorphism was not associated with CaP. We observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein (IGFBP)-3 in modifying CaP risk such that higher IGFBP-3 levels (= versus median) were associated with a reduced risk only among men with the wildtype (OR, 95% CI = 0.74, 0.57-0.97; (Pinteraction) = 0.01). Conclusions: We found no association between these HIF-1alpha gene polymorphisms with CaP, but the interaction between the P582S polymorphism and the IGF axis merits further evaluation in mechanistic studies


Descriptors :   *POLYMORPHISM , *PROSTATE CANCER , PROTEINS , GENES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE