Accession Number : ADA469207


Title :   Oral Administration of N-Acetyl-D-Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses


Descriptive Note : Annual rept. 24 Feb 2006-23 Feb 2007


Corporate Author : FLORIDA ATLANTIC UNIV BOCA RATON


Personal Author(s) : Shibata, Yoshimi


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a469207.pdf


Report Date : Mar 2007


Pagination or Media Count : 71


Abstract : This is an annual report of the 4th grant year. PI and 2 Research Associates moved to the current Institute in 2003 from East Carolina University. The project was re-started in December 2004 with approval of no-cost extension until 5/23/2008. In this grant period, we found that administration of chitin particles resulted in less likely inhibit the production of IL-10. Although chitin particles induce peritoneal macrophages catalytically active COX-2 in vitro, intraperitoneal administration induces peritoneal macrophages catalytically inactive COX-2. COX-2, cyclooxygenase, is necessary enhancing prostaglandin E2 (PGE2) release. Both IL-10 and PGE2 enhance allergic responses. We have also planned to establish a method producing chitin particles at 500 1,000 gram per batch.


Descriptors :   *ALLERGIC DISEASES , CHILDREN , ORAL INTAKE , INGESTION(PHYSIOLOGY) , CHITIN , MACROPHAGES


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE