Accession Number : ADA468515


Title :   Biological Basis for Chemoprevention of Ovarian Cancer


Descriptive Note : Final rept. 1 Oct 2002-30 Sep 2006


Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC


Personal Author(s) : Berchuck, Andrew


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a468515.pdf


Report Date : Oct 2006


Pagination or Media Count : 60


Abstract : To achieve a better understanding of the etiology of ovarian cancer we have initiated a case-control study that considers genetic susceptibility epidemiologic risk factors and acquired genetic alterations. Subjects are interviewed in their homes and about 950 cases and 950 controls have been accrued thus far. Blood and cancer samples have been collected and molecular analyses of polymorphisms in single genes including most recently the androgen receptor have been performed. We also have performed an Illumina array experiment with 1 536 haplotype tagging single nucleotide polymorphisms in about 150 candidate genes. This data presently is being analyzed. We also have played a leadership role in establishing an international consortium in which groups are working together to validate initial positive associations. An initial ovarian cancer chemoprevention trial with levoneorestrel in chickens demonstrated a protective effect and we have shown that progestin mediated apoptosis in the ovarian epithelium is mediated by transforming growth factor-beta. In vitro data has suggested that vitamin D analogues may also represent appealing chemopreventives. A chemoprevention trial in chickens that incorporates both progestins and vitamin D analogues is near completion. These studies have the potential to increase our ability to identify high-risk women and to lead to the development of chemoprevention strategies that might decrease mortality from this disease.


Descriptors :   *OVARIAN CANCER , EPITHELIUM , RISK , LEADERSHIP , MOLECULES , ARRAYS , IN VITRO ANALYSIS , CASE STUDIES , ETIOLOGY , SAMPLING , PROTECTION , GENES , INTERNATIONAL , CHICKENS , CONSORTIUMS , WOMEN , SENSE ORGANS , BLOOD , POLYMORPHISM , CANCER , GROWTH SUBSTANCES , NUCLEOTIDES , ANDROGENS , OVARIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE