Accession Number : ADA467973


Title :   Role of Growth Hormone in Prostate Cancer


Descriptive Note : Final rept. 19 Jan 2004-18 Jan 2007


Corporate Author : ILLINOIS UNIV AT CHICAGO


Personal Author(s) : Swanson, Steven M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a467973.pdf


Report Date : Feb 2007


Pagination or Media Count : 28


Abstract : We have established a GH-deficient prostate cancer model (Tag/Ghdr/dr rat) indicating that a reduction in GH and/or IGF-I can significantly inhibit prostate carcinogenesis in this model in contrast to GH wild-type controls (Probasin/Tag, Tag/Gh+/+). Tag/Gh+/+ Tag/Ghdr/dr and age-matched non-Tag controls were sacrificed at 10, 25 and 52 weeks of age. While real-time RT PCR and immunohistochemical analysis revealed the significantly increased levels of prostate GHR and the dramatically reduced levels of prostate IGF-1R (P0.0001) in Tag/Gh+/+ during prostate cancer progression the loss of prostate GHR and the increase of IGF-1R were observed in Tag/Ghdr/dr. However there was no significant change in either serum or prostate IGF-1 level that can be correlated with prostate cancer progression or the resistance of Tag/Ghdr/dr to prostate carcinogenesis. These findings are consistent with the hypothesis that GH signaling plays a significant role in prostate carcinogenesis and suggest that GH antagonists may be effective agent against prostate cancer.


Descriptors :   *HORMONES , *GROWTH SUBSTANCES , *PROSTATE CANCER , RATS , ONCOGENESIS , PROSTATE GLAND , ANDROGENS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE