Accession Number : ADA466217


Title :   Environmental Survival, Military Relevance, and Persistence of Burkholderia Pseudomallei


Descriptive Note : Final rept. Mar 2005-Dec 2006


Corporate Author : EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD


Personal Author(s) : Inglis, Timothy J ; Sagripanti, Jose-Luis


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a466217.pdf


Report Date : Apr 2007


Pagination or Media Count : 47


Abstract : Burkholderia pseudomallei causes melioidosis, a fatal septicemic infection following either soil or water exposure. The organism is endemic in Asia, where it is able to survive in either desiccated environments or distilled water for several years. The goal of this work was to evaluate available data and to assess the biological hazard posed by B. pseudomallei in environmental water, soil, or on inanimate surfaces. We reviewed the historical impact of melioidosis on the military, clinical aspects of the disease, its laboratory diagnosis, and the molecular and phenotypic characteristics of B. pseudomallei. We then evaluated the effect of geographic environments and habitats (water, soil, climate), as well as physical (ultraviolet radiation, temperature) and chemical (pH, chlorine) factors on the survival of B. pseudomallei. In addition, we analyzed a variety of biological properties that enhance the survival of B. pseudomallei, including metabolic adaptation, biofilm formation, and intracellular survival in protozoa, fungi, and specific parts of legume roots. We identified critical data needed for accurate risk prediction and effective threat reduction of the risk posed by B. pseudomallei. The lack of a vaccine, together with its unusual resistance in the environment, makes B. pseudomallei a concern for public health and bio-defense.


Descriptors :   *CELLS(BIOLOGY) , *MELIOIDOSIS , LABORATORY TESTS , ULTRAVIOLET RADIATION , IMPACT , PREDICTIONS , THREATS , METABOLISM , ASIA , VACCINES , PROTOZOA , DISTILLED WATER , CHLORINE , HAZARDOUS MATERIALS , SURVIVAL(GENERAL) , DIAGNOSIS(MEDICINE) , FUNGI , CLIMATE , HABITATS , PUBLIC HEALTH


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE