Accession Number : ADA463467


Title :   Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-Abdominal Adhesions, and Arterial Injuries


Descriptive Note : Annual rept. 24 Jan 2006-23 Jan 2007


Corporate Author : CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MA


Personal Author(s) : Folkman, Judah ; Puder, Mark ; Bischoff, Joyce


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a463467.pdf


Report Date : Feb 2007


Pagination or Media Count : 78


Abstract : The three goals of this project are: (i) to discover and develop novel drugs which could prevent or reverse the vascular leak syndrome; (ii) to develop angiogenesis inhibitors which would inhibit post-operative abdominal adhesions; and, (iii) to isolate endothelial progenitor cells from blood, capable of being expanded in vitro and applied to vascular grafts. Progress has been made in each category: we have demonstrated suppression of vascular leak by Caplostatin in response to the pro-angiogenic agent VEGF; we have demonstrated that celebrex has an effect on adhesion prevention, and we have two other angiogenesis inhibitors that we would now like to test; and, we have identified cells from cord blood and adult bone marrow that can substitute for mature smooth muscle cells isolated from a healthy vein.


Descriptors :   *ADHESION , *SIGNS AND SYMPTOMS , *IN VITRO ANALYSIS , *CARDIOVASCULAR SYSTEM , *ARTERIES , *STEM CELLS , *ANGIOGENESIS , *WOUNDS AND INJURIES , INHIBITORS , ENDOTHELIUM , SURGICAL TRANSPLANTATION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE