Accession Number : ADA463247


Title :   Prostate Dose Escalation by Innovative Inverse Planning-Driven IMRT


Descriptive Note : Annual rept. 1 Nov 2005-31 Oct 2006


Corporate Author : STANFORD UNIV CA


Personal Author(s) : Xing, Lei


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a463247.pdf


Report Date : Nov 2006


Pagination or Media Count : 201


Abstract : The goal of this project is to develop innovative inverse treatment planning techniques for prostate radiation therapy. In the last funding period significant progress has been made toward the goal of the project. We have established the voxel-based dose optmization framework for lMRT treatment planning. Realizing that current radiation therapy does not adapt to inter-fraction organ movement and dosimetric errors caused by inaccurate patient setup or organ deformation during a course of treatment, we have devised a dynamic dosed-loop control algorithms for adaptive therapy (ART) inverse planning and demonstrate their utility with data from phantom and clinical prostate cases. The inverse planning for ART is particularly relevant considering that the emergence of on-board cone beam CT in the clinics, which affords an effective means to obtain the patient's geometric model just before treatment and recompute on a routine basis the dose to be delivered (or actually delivered) to the patient. Our work makes it possible to adaptively taking the organ deformations and dose delivery history into account. We anticipate that these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of prostate lMRT.


Descriptors :   *DOSAGE , *PATIENTS , *RADIOTHERAPY , *PROSTATE GLAND , DELIVERY , DEFORMATION , CLINICAL MEDICINE , THERAPY , CONICAL BODIES , ORGANS(ANATOMY) , QUALITY ASSURANCE , INVERSION , ADAPTIVE SYSTEMS , GEOMETRIC FORMS , HISTORY


Subject Categories : Anatomy and Physiology
      Radiobiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE