Accession Number : ADA462431


Title :   Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents


Descriptive Note : Final rept. 17 Sep 2001-16 Sep 2006


Corporate Author : HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD


Personal Author(s) : Kalinich, John F ; Miller, Alexandra C ; McClain, David E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a462431.pdf


Report Date : Oct 2006


Pagination or Media Count : 159


Abstract : This study investigated the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium (DU) and a heavy-metal tungsten alloy (WA) consisting of tungsten, nickel, and cobalt. Male Fisher 344 rats were surgically implanted with pellets of DU, WA, tantalum (inert metal, negative control), or nickel (known carcinogen, positive control). Implanted WA resulted in the rapid formation of tumors, identified as rhabdomyosarcomas, surrounding the pellets. These tumors had, within the same area, histopathological characteristics of both the pleomorphic and embryonal subtypes of rhabdomyosarcomas. Eventually these tumors metastasized to the lung. Rats implanted with tantalum or DU pellets did not develop tumors at the implantation site. In addition, WA-implanted rats (high-dose group) exhibited splenomegaly and hematological changes suggesting polycythemia as early as 1 month after pellet implantation.


Descriptors :   *CARCINOGENS , *DEPLETED URANIUM , *HEAVY METALS , *TUNGSTEN ALLOYS , *HEMATOLOGY , *IMMUNOTOXICITY , EMBEDDING , LUNG , PELLETS , BLOOD DISEASES , SPLENOMEGALY , METASTASIS , COBALT , HISTOPATHOLOGY , IMPLANTATION , TANTALUM , RODENTS , NICKEL , INERT MATERIALS


Subject Categories : Medicine and Medical Research
      Toxicology
      Radioactiv, Radioactive Wastes & Fission Prod


Distribution Statement : APPROVED FOR PUBLIC RELEASE