Accession Number : ADA461637


Title :   Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans


Descriptive Note : Annual rept. 1 Oct 2004-14 Mar 2006


Corporate Author : LOMA LINDA VETERANS ASSOCIATION FOR RESEARCH AND EDUCATION CA


Personal Author(s) : Mohan, Subburaman


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a461637.pdf


Report Date : Apr 2006


Pagination or Media Count : 251


Abstract : The primary goal of the proposed work is to identify genes which play an anabolic role in bone and soft tissue function and to clarify the function of these genes. Three hypotheses have been proposed: 1) The high bone density gene in chromosome 1 in our CAST/B6 congenic mice can be cloned; 2) Genes that regulate soft- and hard-tissue regeneration can be identified by using appropriate mouse strains that exhibit differences in regeneration; and 3) ENU mutagenesis, applied to our mouse model, will lead to the identity of genes that regulate soft and hard tissue function. During the last funding period, we have proposed several specific objectives for each of the above-mentioned hypotheses. As disclosed in the progress report, we have successfully accomplished all of the specific objectives. Our work during the first year of the funding period has resulted in two manuscripts in press, two published manuscripts, and three abstracts. We believe that the successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in hard- and soft-tissue regeneration and will provide a framework for future development of therapies for hard and soft tissue injuries.


Descriptors :   *TISSUES(BIOLOGY) , *GENES , *HARDNESS , *SOFT TISSUES , *WOUNDS AND INJURIES , *REGENERATION(PHYSIOLOGY) , *BONE FRACTURES , DENSITY , HUMANS , ABSTRACTS , HYPOTHESES , HEALING , BONES , ANATOMICAL MODELS , MOLECULAR PROPERTIES , MICE , CLONES , MUTATIONS , REPAIR , STRAINS(BIOLOGY) , THERAPY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE