Accession Number : ADA456135


Title :   Summer Student Breast Cancer Research Training Program


Descriptive Note : Annual summary rept. 15 Apr 2003-14 Apr 2006


Corporate Author : CLARIAN HEALTH PARTNERS INC INDIANAPOLIS IN


Personal Author(s) : Zaloga, Gary P ; Spear, Karen L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a456135.pdf


Report Date : May 2006


Pagination or Media Count : 55


Abstract : The purpose of the Breast Cancer Research Training Program is to recruit and train potential future researchers in breast cancer research. During the 3-year grant, we recruited 75 applicants to the program, interviewed 22 candidates, and hired 15 students. Each year, students attended up to 7 research lectures, participated in weekly meetings, developed and carried out research projects under the supervision of their mentors, and presented their projects to a research audience. Projects conducted over the course of the grant built upon previous years' research. Ongoing research was conducted on the anticancer properties of an Asian mushroom, Ganoderma lucidum, upon highly invasive breast cancer cells, on the role of omega-3 fatty acids in preventing and treating breast cancer, and in the mechanisms by which C-reactive protein exerts its anticancer properties in breast cancer. Other projects addressed the effect of kinase inhibition on ERK activity in breast cancer cells, the role of the calpain proteolytic pathway in breast cancer-induced cachexia, and the inhibitory effects of a Japanese mushroom, Phellinus linteus, in breast cancer cells. These results have added significant new information to our understanding of dietary modulation of breast cancer and have provided 15 students with experience in breast cancer research.


Descriptors :   *MEDICAL RESEARCH , *BREAST CANCER , PREVENTIVE MAINTENANCE , CELLS(BIOLOGY) , NUTRITION , PHOSPHORUS TRANSFERASES , FATTY ACIDS , DIET , STUDENTS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE