Accession Number : ADA453641


Title :   Evidence of Rickettsial and Leptospira Infections in Andean Northern Peru


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH INST DETACHMENT LIMA (PERU)


Personal Author(s) : Blair, Patrick J ; Schoeler, George B ; Moron, Cecilia ; Anaya, Elizabeth ; Caceda, Roxana ; Cespedes, Manuel ; Cruz, Christopher ; Felices, Vidal ; Guevara, Carolina ; Huaman, Alfredo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a453641.pdf


Report Date : Jan 2004


Pagination or Media Count : 8


Abstract : Between May and October 2002, a cluster of acute febrile illnesses occurred in the subtropical Andean foothills of Peru. Serologic evidence in villages where disease had been documented showed that the prevalence of IgM antibody to Leptospira ranged from 6% to 52%, that of IgM antibody to spotted fever group (SFG) rickettsia ranged from 10% to 19%, and that of IgM antibody to Coxiella burnetii from 1% to 15%. Measurement of IgG antibodies for SFG rickettsiae suggested that this disease was endemic. In contrast, IgG antibodies against C. burnetii were largely absent. In humans, microagglutination tests identified pathogenic variants of Leptospira. The presence of an SFG rickettsial infection was confirmed in four febrile patients following polymerase chain reaction and sequencing of the conserved 17-kD common antigen gene (htrA). Collectively, these analyses indicated that Rickettsia sp., C. burnetii, and Leptospira sp. were circulating in the region during the time of disease outbreak and implicate the involvement of an as yet undetermined SFG rickettsia in northwestern Peru.


Descriptors :   *DISEASES , *PERU , *LEPTOSPIRA , *RICKETTSIA , *COXIELLA BURNETII , REPRINTS , IMMUNOGLOBULINS , LEPTOSPIROSIS , ZOONOTIC DISEASES


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE