Accession Number : ADA450022


Title :   Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-Abdominal Adhesions, and Arterial Injuries


Descriptive Note : Annual rept.


Corporate Author : CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MA


Personal Author(s) : Folkman, Judah ; Puder, Mark ; Bischoff, Joyce


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a450022.pdf


Report Date : Feb 2006


Pagination or Media Count : 35


Abstract : The three goals of this project are: (i) to discover and develop novel drugs which could prevent or reverse the vascular leak syndrome; (ii) to develop angiogenesis inhibitors which would inhibit post-operative abdominal adhesions; and (iii) to isolate endothelial progenitor cells from blood capable of being expanded in vitro and applied to vascular grafts. Progress has been made in each category: we are elucidating the mechanism of Caplostatin one of the most potent anti-vascular leak drugs; we have been able to prevent intra-abdominal adhesions effectively by the use of the anti-angiogenic activity of celecoxib; and we have identified conditions for expanding endothelial progenitor cells and smooth muscle progenitor cells obtained from umbilical cord blood so that they can eventually be grown in vascular grafts.


Descriptors :   *ADHESION , *SIGNS AND SYMPTOMS , *IN VITRO ANALYSIS , *ARTERIES , *STEM CELLS , *ANGIOGENESIS , *CARDIOVASCULAR SYSTEM , *WOUNDS AND INJURIES , *ENDOTHELIUM , MUSCLES , UMBILICAL CORDS(AEROSPACE) , INHIBITORS , DRUGS , BLOOD CELLS , SURGICAL TRANSPLANTATION , ABDOMEN , CELLS(BIOLOGY)


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE