Accession Number : ADA447654


Title :   The BESCT Lung Cancer Program (Biology, Education, Screening, Chemoprevention, and Treatment)


Descriptive Note : Annual rept. 16 Feb 2004-15 Feb 2005


Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX


Personal Author(s) : Hong, Waun K ; Khuri, Fadlo R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a447654.pdf


Report Date : Mar 2005


Pagination or Media Count : 172


Abstract : Lung cancer is a devastating worldwide public health hazard. Advances in surgery, radiation therapy, and chemotherapy of non-small cell lung cancer (NSCLC) have only led to a marginal improvement in five-year survival. To reduce lung cancer incidence and mortality, it is imperative to develop effective therapeutic and preventive strategies targeting smokers and lung cancer patients. Our long-term objectives are to define the molecular processes contributing to lung cancer development and progression in order to recognize genetic and phenotypic changes early enough to be reversed with molecular targeted therapy and to develop innovative therapeutic approaches to lung cancer. The objectives can be achieved only by understanding the biology of lung cancer through molecular studies and preclinical experimental molecular therapeutic research. Therefore, the specific goals of this program are to understand molecular alterations in lung cancer develop lung cancer prevention strategies and implement experimental molecular approaches to lung cancer.


Descriptors :   *BIOLOGY , MOLECULES , PUBLIC HEALTH , GENETICS , PREVENTIVE MEDICINE , CHEMOTHERAPY , RADIOTHERAPY , LUNG CANCER


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE