Accession Number : ADA446399


Title :   Cyclin Dependent Kinase Inhibitors as Targets in Ovarian Cancer


Descriptive Note : Final rept. 29 Sep 2001-28 Sep 2005


Corporate Author : INDIANA UNIV INDIANAPOLIS


Personal Author(s) : Williams, Stephen D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a446399.pdf


Report Date : Oct 2005


Pagination or Media Count : 97


Abstract : The objective of this proposal is to develop gene therapy strategies that inhibit ovarian cancer cell growth and selectively improve sensitivity of ovarian cancer cells to chemotherapy and radiation. The proposal focuses on invitro and in vivo %proof- of-concept studies of target discovery. Four highly interactive projects make up this proposal. We have identified key genes that may be effective targets in ovarian cancer therapy. The first three projects seek to identify alterations in these genes which, either alone or in combination with chemotherapy or radiation, will efficiently kill ovarian cancer cells. Project 4 will identify promoters that allow for high expression of our key gene(s) in ovarian cancer cells but minimal expression in normal tissues.


Descriptors :   *OVARIAN CANCER , TISSUES(BIOLOGY) , DEOXYRIBONUCLEIC ACIDS , INHIBITORS , CELLS(BIOLOGY) , GENE THERAPY , RECOMBINANT DNA , GENETIC DISEASES , CHEMOTHERAPY , NORMALITY , PHOSPHORUS TRANSFERASES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE