Accession Number : ADA446266


Title :   In Vitro Toxicity of Aluminum Nanoparticles in Rat Alveolar Macrophages


Descriptive Note : Master's thesis


Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING AND MANAGEMENT


Personal Author(s) : Wagner, Andrew J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a446266.pdf


Report Date : Mar 2006


Pagination or Media Count : 111


Abstract : The purpose of this research is to characterize the in vitro cellular effects of rat lung macrophages to exposure to aluminum oxide nanoparticles (Al2O3-NP) (30 and 40nm) compared to aluminum nanoparticles (Al-NP) (50, 80, and 120nm). This study concentrates on cell viability, mitochondrial function, phagocytosis ability, and cytokine response. Results indicate no to minimal toxicological effects on macrophages exposed as high as 500 μg/ml for 24 hours with Al2O3-NP. However, there was a significant delayed toxicity that occurred at 96 and 144 h post exposure. Al-NP shows sight to moderate toxicity after 24 h exposure at 100 and 250 μg/ml. The phagocytic ability of these cells was significantly hindered by exposure to each size of the Al-NP at 25 μg/ml for 24 hours, but not by the Al2O3-NP. A series of cytokine and nitric oxide assays performed show none of these aluminum nanoparticles are inducing an inflammatory response.


Descriptors :   *TOXICITY , *IN VITRO ANALYSIS , *MACROPHAGES , *ALUMINUM OXIDES , FUNCTIONS , ALUMINUM , DELAY , RESPONSE(BIOLOGY) , INFLAMMATION , NITRIC OXIDE , CYTOKINES , MITOCHONDRIA , PHAGOCYTES , RETICULOENDOTHELIAL SYSTEM , ALVEOLI , TOXICOLOGY , ASSAYING , CELLS(BIOLOGY) , LUNG , VIABILITY , PARTICLES , THESES , RATS


Subject Categories : Anatomy and Physiology
      Toxicology
      Inorganic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE