Accession Number : ADA438562


Title :   A System for Discovering Bioengineering Threats by Knowledge Base Driven Mining of Toxin Data


Descriptive Note : Annual rept. 1 Aug 2004-31 Jul 2005


Corporate Author : BROOKHAVEN NATIONAL LAB UPTON NY


Personal Author(s) : Swaminathan, Subramanyam ; Ramakrishnan, I V ; Kifer, M ; Davulcu, H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a438562.pdf


Report Date : Aug 2005


Pagination or Media Count : 33


Abstract : The overall goal of this project is to establish a Toxin Knowledge Base (TKB) a bioinformatics resource primarily focused on molecular information about toxins and other virulence factors that are the natural products of biological and potential biological warfare (RW and PBW) agents. The resource will be mined to assimilate synthesize, analyze and disseminate genomic and structural information on BW and PBW genes and their products. The TKB will be designed and developed to serve as a powerful analysis and decision system tool for the intelligence community. In this first annual report we describe in detail the TKB system that we have developed that can be used to identify homologs of toxins. The TKB contains molecular, biological and structural information of about 1000 toxins and is still being expanded. TKB will also use innovative computer methods to parse the literature available in public resources (web sites) to identify% new and emerging toxins to be included in the database.


Descriptors :   *DATA BASES , *THREATS , *MINING ENGINEERING , *KNOWLEDGE BASED SYSTEMS , *TOXINS AND ANTITOXINS , INTELLIGENCE , BIOLOGICAL WARFARE , VIRULENCE , GENOME , BIOENGINEERING , INTERNET , GENES , COMPUTER APPLICATIONS , NATURAL RESOURCES , STRUCTURAL PROPERTIES , DECISION MAKING


Subject Categories : Toxicology
      Mining Engineering
      Military Operations, Strategy and Tactics


Distribution Statement : APPROVED FOR PUBLIC RELEASE