Accession Number : ADA438021


Title :   Bacillus anthracis Edema Toxin Inhibits Staphylococcus aureus Enterotoxin B Effects in Vitro: A Potential Protein Therapeutic?


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Krakauer, Teresa ; Little, Stephen F ; Stiles, Bradley G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a438021.pdf


Report Date : Oct 2005


Pagination or Media Count : 6


Abstract : Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated by Bacillus anthracis edema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha MIP-1alpha, MIP-1beta) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen.


Descriptors :   *ENTEROTOXINS , *BACILLUS ANTHRACIS , *EDEMA , IN VITRO ANALYSIS , ANTHRAX , CYTOKINES , ANTIGENS , STAPHYLOCOCCUS , EXOTOXINS , BLOOD CELLS


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE