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Potentiation of T Lymphocyte Responses by Modulating NF-kB Activity in Dendritic Cells
Annual rept. 1 May 2003-30 Apr 2004
COLUMBIA UNIV NEW YORK
Pagination or Media Count:
The goal of this investigation is to determine whether modulation of NF-kappa beta activity by genetic engineering of DCs can affect DC longevity and T cell stimulatory functions. The specific aims are 1 To determine the effect of expression of constitutively-active IK beta I kappa beta kinase on nuclear NF-kappa beta levels in DCs, and on the longevity of DCs. 2 To determine beta expression on in vitro and in vivo T cell priming by DCs. Results from these studies may thus lead the way for development of approaches for enhancing DC survival and function, with the goal of generating potent anti-tumor immunity.
APPROVED FOR PUBLIC RELEASE