Accession Number : ADA436057


Title :   The Potential Neurotoxic Effects of Low-Dose Sarin Exposure in a Guinea Pig Model


Descriptive Note : Conference paper


Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD DEPT OF PHARMACY


Personal Author(s) : Roberson, Melinda R ; Schmidt, Michelle B ; Gonzales, Mary D ; McDonough, John H , Jr


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a436057.pdf


Report Date : Jan 2002


Pagination or Media Count : 8


Abstract : This study is assessing the effects in guinea pigs of repeated low-dose exposure to the nerve agent sarin. Preliminary results suggest no effects of either repeated 0.2 or 0.4 X LD50 sarin exposure (compared with saline) on body weight or temperature, general physical signs, flinch threshold or activity level, or on EEG activity. In contrast, RBC cholinesterase levels dropped to 20% of baseline following the tenth exposure in the 0.4 group. Since this study is ongoing, data from receptor binding and brain cholinesterase assays and histopathology are still being collected and analyzed, and may be influenced by the dramatic changes in cholinesterase activity.


Descriptors :   *CHOLINESTERASE , *NERVE AGENTS , *GB AGENT , *NEUROTOXINS , SYMPOSIA , DOSAGE , EXPOSURE(PHYSIOLOGY) , RECEPTOR SITES(PHYSIOLOGY) , CHEMICAL WARFARE AGENTS , HISTOPATHOLOGY , GUINEA PIGS


Subject Categories : Biochemistry
      Pharmacology
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE