Accession Number : ADA435748


Title :   On-Chip Hardware for Cell Monitoring: Contact Imaging and Notch Filtering


Descriptive Note : Final rept. 16 Apr 2004-7 Jul 2005


Corporate Author : MARYLAND UNIV COLLEGE PARK


Personal Author(s) : Abshire, Pamela ; Smela, Elisabeth ; Shapiro, Benjamin


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a435748.pdf


Report Date : 07 Jul 2005


Pagination or Media Count : 7


Abstract : The cell canary system will combine live bio-engineered cells with on-chip MEMS hardware. It will function by monitoring the response of many live cells to an external environment. Each cell, or cell colony, will be bio-engineered to fluoresce in response to a specific external pathogen. The fluorescence will occur through a FRET interaction with a quantum dot that labels a component of the pathway. If the cell or cell colony dies due to the presence of its target pathogen, then it will fluoresce as it dies; if the cell or cell colony dies due to other factors, then it will not fluoresce. The system will therefore act as a cell canary system for specific, low-false-positive detection of pathogens. Our goal here is to demonstrate proof-of-concept for the on-chip fluorescence detection portion of the project.


Descriptors :   *CHIPS(ELECTRONICS) , *CELLS(BIOLOGY) , FLUORESCENCE , MONITORING , DIES , IMAGES , FILTERS , QUANTUM DOTS


Subject Categories : Electrical and Electronic Equipment
      Optics
      Quantum Theory and Relativity


Distribution Statement : APPROVED FOR PUBLIC RELEASE