Accession Number : ADA433978


Title :   Skin Bioengineering: Noninvasive Transdermal Monitoring


Descriptive Note : Final rept. 1 Jan 2003-31 Dec 2004


Corporate Author : GENEVA UNIV (SWITZERLAND)


Personal Author(s) : Guy, Richard H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a433978.pdf


Report Date : Jan 2005


Pagination or Media Count : 92


Abstract : The long-term objective is to develop and optimize a novel, noninvasive, iontophoretic approach for metabolic monitoring via the skin. The low-level current density drives both charged and highly polar (yet neutral) compounds across the skin at rates much greater than passive diffusion. As the skin offers a uniquely accessible body surface across which information can be extracted, we hypothesize that truly noninvasive and highly sensitive devices, which exploit uniquely paired flows of at least two substances, can be developed for iontophoretic monitoring applications. Proof-of-principle targets two analytes of significant interest; specifically, glucose and lactate.


Descriptors :   *METABOLISM , *SKIN(ANATOMY) , *BIOENGINEERING , MONITORING , PASSIVE SYSTEMS , CURRENT DENSITY , SENSITIVITY , GLUCOSE , LACTATES , SWITZERLAND


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE