Accession Number : ADA430556


Title :   Effects of Moderate Aerobic Exercise Combined With Calorie Restriction on Circulating Estrogens and IGF-I in Premenopausal Women


Descriptive Note : Annual summary rept. 17 Sep 2003-16 Sep 2004


Corporate Author : PENNSYLVANIA STATE UNIV STATE COLLEGE


Personal Author(s) : Williams, Nancy I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a430556.pdf


Report Date : Oct 2004


Pagination or Media Count : 44


Abstract : This proposal entitled effects of moderate aerobic exercise combined with caloric restriction on circulating estrogens and IGF-1 in premenopausal women will provide important contributions regarding the primary prevention of breast cancer in women. This study has examined the effects of exercise training combined with caloric restriction, resulting in weight loss, on two hormonal biomarkers for breast cancer i.e., circulating estrogens and insulin-like growth factor I (IGF-I). As expected, exercise training 4 times per week combined with an 20-30% decrease in caloric intake over four menstrual cycles has produced significant increases in aerobic capacity (28-33%), weight loss ranging from 1.0 to 9 kg, and loss of body fat ranging from 5 to 12% of initial percent fat. Light conditioning resulted in significant gains in aerobic capacity (33%), but only produced a trend toward a decrease in body fat percent (-3.1%), and no changes in body weight. Despite the highly significant changes in body composition and body weight in the exercising group, preliminary results indicate no significant changes in serum estradiol or serum estrone. IGF-I did not change significantly either, indicating that chronic exercise and dieting do not result in favorable changes in two hormonal biomarkers for breast cancer.


Descriptors :   *BREAST CANCER , *ESTROGENS , *EXERCISE(PHYSIOLOGY) , *GROWTH(PHYSIOLOGY) , *HORMONES , *WEIGHT REDUCTION , ADIPOSE TISSUE , AEROBIC PROCESSES , BLOOD SERUM , BODY WEIGHT , CALORIFIC VALUE , CAPACITY(QUANTITY) , CIRCULATION , CYCLES , DIET , HUMAN BODY , INSULIN , MARKERS , MENSTRUATION , PREVENTION , TRACER STUDIES , TRAINING , WOMEN


Subject Categories : Biology
      Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE