Accession Number : ADA429843


Title :   Protein Kinase Pathways That Regulate Neuronal Survival and Death


Descriptive Note : Final rept. 1 Aug 1999-31 Jul 2004


Corporate Author : COLORADO UNIV HEALTH SCIENCES CENTER DENVER


Personal Author(s) : Heidenreich, Kim A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a429843.pdf


Report Date : Aug 2004


Pagination or Media Count : 110


Abstract : Loss of post-mitotic neurons from the adult brain underlies the pathology of neurodegenerative diseases and neurotoxin exposure. Neuronal cell death occurs by two mechanisms: necrosis and apoptosis. Apoptosis is a process whereby developmental cues and environmental stimuli activate a genetic program to implement a series of steps that culminate in cell death. An important aspect of apoptosis is that it can be halted and such interventions may rescue dying neurons. The overall goal of this project is to identify key protein kinases involved in regulating neuronal survival and apoptosis. The progress made in these areas has resulted in 4 published manuscripts (plus 2 submitted articles) and 9 abstracts presented at national and international scientific meetings in 2002.


Descriptors :   *BRAIN , *EXPOSURE(PHYSIOLOGY) , *NEUROLOGY , *SURVIVAL(PERSONNEL) , *CELLS(BIOLOGY) , *APOPTOSIS , ENZYMES , DISEASES , DEATH , GENETICS , ADULTS , CNS DEPRESSANTS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE