Accession Number : ADA429304


Title :   Georgetown Institute for Cognitive and Computational Sciences


Descriptive Note : Final rept. 1 Apr 2001-31 Mar 2004, phase 3


Corporate Author : GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER


Personal Author(s) : Faden, Alan I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a429304.pdf


Report Date : Apr 2004


Pagination or Media Count : 513


Abstract : Understanding and modifying plasticity/recovery within the central nervous system (CNS) represents the over-arching theme of this multidisciplinary research program. Participating investigators have used tools from cellular and molecular neurobiology, as well as systems neuroscience, to study mechanisms of neuronal cell death, as well as plasticity, after acute or chronic CNS injury. This included development/evaluation of pharmacological strategies to limit tissue damage and enhance recovery after acute or chronic neurodegeneration. Magnetic resonance imaging and spectroscopy were utilized as tools to evaluate changes in response to injury and/or treatment. Computational modeling was also used to predict both plasticity and for drug discovery. Together, these complementary research efforts were intended to elucidate mechanisms/processes relating to CNS injury and plasticity, with particular reference to language disorders, traumatic brain injury, spinal cord injury, and Alzheimer's disease.


Descriptors :   *RECOVERY , *PLASTIC PROPERTIES , *NERVE CELLS , *CENTRAL NERVOUS SYSTEM , *APOPTOSIS , TISSUES(BIOLOGY) , MODELS , SPECTROSCOPY , COGNITION , GENES , SPINAL CORD , BRAIN DAMAGE , NEUROBIOLOGY , MAGNETIC RESONANCE IMAGING , ALZHEIMER DISEASE


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Atomic and Molecular Physics and Spectroscopy


Distribution Statement : APPROVED FOR PUBLIC RELEASE