Accession Number : ADA426745


Title :   Interferon-Beta 1a and SARS Coronavirus Replication


Descriptive Note : Journal article


Corporate Author : CHILDREN'S HOSPITAL CINCINNATI OH


Personal Author(s) : Hensley, Lisa E ; Fritz, Elizabeth A ; Jahrling, Peter B ; Karp, Christopher L ; Huggins, John W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a426745.pdf


Report Date : Feb 2004


Pagination or Media Count : 4


Abstract : A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro.


Descriptors :   *SIGNS AND SYMPTOMS , *RESPIRATORY SYSTEM , IN VITRO ANALYSIS , DRUGS , ANTIVIRAL AGENTS , DEATH , PUBLIC HEALTH


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE