Accession Number : ADA416868


Title :   Preeclampsia-Associated Hormonal Profiles and Reduced Breast Cancer Risk Among Older Mothers


Descriptive Note : Final rept. 30 Sep 2000-31 Mar 2003


Corporate Author : COLORADO UNIV AT FITZSIMMONS AURORA HEALTH SCIENCES CENTER


Personal Author(s) : Laudenslager, Mark L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a416868.pdf


Report Date : Apr 2003


Pagination or Media Count : 9


Abstract : Preeclampsia has been linked to reduced breast cancer risk, and this reduction may be especially marked among women who bear their first child later in life. In this ongoing case-control study, we examine the hormonal profiles of older Colorado mothers with and without a history of preeclampsia in their first pregnancies. Subjects are nonpregnant, non-smoking women who completed their first pregnancies at age 30 or older, are currently premenopausal, and are free of serious chronic disease. Cases are 14 Denver area women who experienced preeclampsia in their first pregnancy; controls are 13 women with uncomplicated first pregnancies, frequency matched to cases on race/ethnicity, current age, age at delivery, and breast-feeding status. A fasting blood and saliva sample was collected from each subject during the luteal phase (day 19-22) of the menstrual cycle and assayed for specific steroid and peptide hormones thought to be linked to breast cancer.


Descriptors :   *HORMONES , *BREAST CANCER , PEPTIDES , PROFILES , CASE STUDIES , RACE(ANTHROPOLOGY) , ETHNIC GROUPS , PREGNANCY , COLORADO , SALIVA , MENSTRUATION , STEROIDS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE