Accession Number : ADA415382


Title :   Effects of Moderate Aerobic Exercise Combined with Caloric Restriction on Circulating Estrogens and IGF-I in Premenopausal Women


Descriptive Note : Annual summary rept. 17 Sep 2001-16 Sep 2002


Corporate Author : PENNSYLVANIA STATE UNIV STATE COLLEGE


Personal Author(s) : Williams, Nancy I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a415382.pdf


Report Date : Oct 2002


Pagination or Media Count : 26


Abstract : This investigator has received a Career Development Award (DAMDl7-01-1-0360 and an IDEA award (DAMDl7-01-1-0361) to support her development as a breast cancer researcher, and to conduct a study to test whether a program of moderate aerobic exercise that is combined with a moderate level of dietary restriction will result in significant decreases in two biomarkers of breast cancer, circulating estrogens and IGF-1. The study will test whether a diet(exercise program will produce significant reductions in the peripheral production of estrone by adipose tissue through its impact on the reduction of fat mass. Lastly, validation studies for a novel method of assessing energy status will be performed. The annual summary for this study has been submitted with the IDEA award The support Dr. Williams has received from the CDA award has allowed her release from 66% of her teaching responsibilities, provided support for travel to the Era of Hope meeting and supported a graduate student. These funds have therefore indirectly helped to support numerous research and training accomplishments that are listed in this report.


Descriptors :   *BREAST CANCER , ADIPOSE TISSUE , AEROBIC PROCESSES , CALORIFIC VALUE , DIET , ESTROGENS , EXERCISE(PHYSIOLOGY) , FATS , INSULIN , MENSTRUATION


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE