Accession Number : ADA360800


Title :   Quantitation of TCE-Induced Radicals in Liver of B6C3Fl Mice In Vivo: An EPR Study


Descriptive Note : Interim rept. Jun 94-Aug 95


Corporate Author : MANTECH-GEOCENTERS JOINT VENTURE DAYTON OH


Personal Author(s) : Steel-Goodwin, Linda ; Hurtle, William ; Schmidt, William J. ; Berty, Sara ; Drerup, Joanne


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a360800.pdf


Report Date : FEB 1996


Pagination or Media Count : 105


Abstract : The total radicals generated in liver of B6C3Fl mice in vivo following exposure five days per week for 60 days to water, corn oil, or corn oil supplemented with trichloroethylene (TCE) was determined by EPR/spin trapping techniques. The concentration of the TCE added to the corn oil was 400, 800 or 1200 mg/kg body weight. Mice were gavaged with test material every day at 0900 and on the day of harvest at 1300 the mice were injected with spin trap 50 mg N-tert-butyl-a-nitrone/kg BW thirty minutes before euthanization by CO2 inhalation.


Descriptors :   *PHYSIOLOGICAL EFFECTS , *TRICHLOROETHYLENE , TISSUES(BIOLOGY) , OXIDATION , EXPOSURE(PHYSIOLOGY) , RESPONSE(BIOLOGY) , FREE RADICALS , MICE , LIVER , LIQUID NITROGEN , ELECTRON PARAMAGNETIC RESONANCE , CHLORINATED HYDROCARBONS , CORN , LYOPHILIZATION , HISTOLOGICAL TECHNIQUES , ASCORBATES.


Subject Categories : BIOCHEMISRTY
      ANATOMY AND PHYSIOLOGY
      PHYSICAL CHEMISTRY
      ATOMIC AND MOLECULAR PHYSICS AND SPECTROSCOPY


Distribution Statement : APPROVED FOR PUBLIC RELEASE