Accession Number : ADA360800
Title : Quantitation of TCE-Induced Radicals in Liver of B6C3Fl Mice In Vivo: An EPR Study
Descriptive Note : Interim rept. Jun 94-Aug 95
Corporate Author : MANTECH-GEOCENTERS JOINT VENTURE DAYTON OH
Personal Author(s) : Steel-Goodwin, Linda ; Hurtle, William ; Schmidt, William J. ; Berty, Sara ; Drerup, Joanne
Report Date : FEB 1996
Pagination or Media Count : 105
Abstract : The total radicals generated in liver of B6C3Fl mice in vivo following exposure five days per week for 60 days to water, corn oil, or corn oil supplemented with trichloroethylene (TCE) was determined by EPR/spin trapping techniques. The concentration of the TCE added to the corn oil was 400, 800 or 1200 mg/kg body weight. Mice were gavaged with test material every day at 0900 and on the day of harvest at 1300 the mice were injected with spin trap 50 mg N-tert-butyl-a-nitrone/kg BW thirty minutes before euthanization by CO2 inhalation.
Descriptors : *PHYSIOLOGICAL EFFECTS , *TRICHLOROETHYLENE , TISSUES(BIOLOGY) , OXIDATION , EXPOSURE(PHYSIOLOGY) , RESPONSE(BIOLOGY) , FREE RADICALS , MICE , LIVER , LIQUID NITROGEN , ELECTRON PARAMAGNETIC RESONANCE , CHLORINATED HYDROCARBONS , CORN , LYOPHILIZATION , HISTOLOGICAL TECHNIQUES , ASCORBATES.
Subject Categories : BIOCHEMISRTY
ANATOMY AND PHYSIOLOGY
ATOMIC AND MOLECULAR PHYSICS AND SPECTROSCOPY
Distribution Statement : APPROVED FOR PUBLIC RELEASE