Accession Number : ADA358078


Title :   Cell Growth Arrest Mediated by STAT Proteins in Breast Cancer Cells


Descriptive Note : Annual rept. 1 Jul 1997-30 Jun 1998


Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE


Personal Author(s) : Iwamoto, Yoshiki


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a358078.pdf


Report Date : Jul 1998


Pagination or Media Count : 37


Abstract : Many growth factors, including epidermal growth factor (EGF), can activate the signal transducer and activator of transcription (STAT) signaling pathway. Here, we demonstrate that STAT activation by EGF treatment is conditional: EGF activates STAT1 and STAT3 in A431 but not in HeLa and PCl2 cells. Using a reconstituted in vitro STAT activation system, we have identified and partially purified a potential inhibitor (s) that is membrane associated and can block STAT activation induced by EGF in vitro. However, this inhibitor has no effect on STAT complexes after they are formed. We have further shown that this inhibitor(s) also exists in many other cancer cell lines, suggesting that blocking the STAT activation during EGF signal transduction may play a significant role in the development of many kinds of cancers.


Descriptors :   *ARRESTING(PROCESS) , *BREAST CANCER , *CELLS(BIOLOGY) , *GROWTH(PHYSIOLOGY) , *MEDICAL RESEARCH , ACTIVATION , CANCER , EPIDERMIS , IN VITRO ANALYSIS , INHIBITORS , PROTEINS , SIGNALS


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE