Accession Number : ADA298874


Title :   Trichloroethylene: Metabolism and Other Biological Determinants of Mouse Liver Tumors


Descriptive Note : Final rept. Jul 1993-Apr 1994


Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH


Personal Author(s) : Barton, H A ; Byczkowski, J Z ; Channel, S R ; Jarnot, B M ; Lipscomb, J C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a298874.pdf


Report Date : Sep 1994


Pagination or Media Count : 79


Abstract : Trichioroethylene (TCE) is one of the most commonly found groundwater contaminants at DoD facilities due to its widespread use in degreasing and as a solvent in other operations. Trichioroethylene has been the subject of extensive study including a large number of lifetime studies in laboratory rodents exposed by inhalation and oil gavage (oral bolus dosing). Several toxicities have been identified, including both noncarcinogenic and carcinogenic effects. This review considers both pharmacokinetic and pharmacodynamic factors that could act as determinants of TCE carcinogenesis. The implications of these data are to suggest that alternatives to the current risk assessment for TCE-induced cancer should be seriously considered.


Descriptors :   *BIOLOGICAL CONTAMINATION , *GROUND WATER , *CONTAMINANTS , *TRICHLOROETHYLENE , RISK , TOXICITY , NEOPLASMS , METABOLISM , LABORATORIES , PHARMACOKINETICS , MICE , LIVER , RODENTS , LIFE SPAN(BIOLOGY) , PHARMACOLOGY , INHALATION , ONCOGENESIS


Subject Categories : Organic Chemistry
      Water Pollution and Control
      Environmental Health and Safety


Distribution Statement : APPROVED FOR PUBLIC RELEASE