Accession Number : ADA281635


Title :   World Reference Center for Arboviruses


Descriptive Note : Final rept. 9 Feb 1990-8 Dec 1993


Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE


Personal Author(s) : Shope, Robert E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a281635.pdf


Report Date : 07 Jun 1994


Pagination or Media Count : 13


Abstract : The World Reference Center for Arboviruses Characterized Sabia and Guanarito viruses, two new arenaviruses causing hemorrhagic fever in Brazil and Venezuela, respectively. A new genotype of Japanese encephalitis virus was discovered from Indonesia. Classifications of Venezuelan encephalitis and arenaviruses were revised. Outbreaks of arenavirus hemorrhagic fever in Venezuela and Brazil were investigated. Military watchdogs had antibody to Japanese encephalitis virus. Rapid PCR-based diagnostic techniques for encephalitides were developed. Neutralization tests of sera of army volunteers supported the licensing of the Japanese encephalitis inactivated vaccine. Recombinant vaccinia viruses expressing the prM/E genes were developed as candidate vaccines. Reagents were distributed to laboratories in 24 countries.


Descriptors :   *MILITARY MEDICINE , *VACCINES , *ARBOVIRUSES , TEST AND EVALUATION , MILITARY PERSONNEL , RECOMBINATION REACTIONS , RIFT VALLEY FEVER , DENGUE , MILITARY DOGS , JAPANESE B ENCEPHALITIS VIRUS , YELLOW FEVER , NAVIGATION REFERENCE , VIRUSES , HEMORRHAGIC FEVERS , ANTIBODIES , DIAGNOSIS(MEDICINE)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE