Accession Number : ADA277748


Title :   Chronic Liver Disease in Peru: Role of Viral Hepatitis


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Barham, W B ; Figueora, R ; Phillips, I A ; Hyams, K C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a277748.pdf


Report Date : Jan 1994


Pagination or Media Count : 5


Abstract : The prevalence of antibodies to hepatitis C virus (anti-HCV) was determined in 105 patients with biopsy-proven chronic liver disease and 128 comparison patients without any evidence of liver pathology living in Lima, Peru. Using a second-generation EIA screening and supplemental immunoblot assay, anti-HCV was detected in four of 13 patients with chronic hepatitis, in 11% of 85 patients with cirrhosis, and none of seven patients with hepatocellular carcinoma. Only two (1.6%) comparison patients without liver disease had anti- HCV. Hepatitis B surface antigen (HBsAg) was found in 23% of patients with chronic hepatitis, 12% of patients with cirrhosis, and three of seven patients with hepatocellular carcinoma. There was no evidence of chronic viral hepatitis or alcohol abuse (reported by one-third of subjects) in 48% of chronic liver disease patients. These preliminary data suggest that among this South American population neither hepatitis B nor hepatitis C infection is the predominate cause of chronic liver disease and that other infectious or environmental factors may be important.


Descriptors :   *HEPATITIS , *HEPATITIS VIRUSES , *LIVER DISEASES , REPRINTS , CLINICAL MEDICINE , ANTIBODIES , PERU , PATIENTS , INFECTIOUS DISEASES , MEDICAL RESEARCH


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE