Accession Number : ADA275299


Title :   The Influence of Multiple Host Contacts on the Acquisition and Transmission of Dengue-2 Virus


Descriptive Note : Doctoral thesis


Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH


Personal Author(s) : Putnam, John L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a275299.pdf


Report Date : Jan 1993


Pagination or Media Count : 106


Abstract : I tested assumptions of the hypothesis that multiple host contacts by Ae. aegypti contribute to dengue virus transmission, the hypothesis assumes multiple meals that combine a viremic meal with a meal from an immune host will not interfere with mosquito infection. I administered enemas, which simulated a second meal from an immune host, to Ae. aegypti that had fed 24 hours earlier from a drop of dengue-2 virus infected blood. Infection rates of the mosquitoes receiving immune sera (85%) were significantly lower than the controls (92%). Lower infection rates reduce the potential for virus transmission. In vitro transmission rates of the mosquitoes that become infected were not altered by the immune sera.


Descriptors :   *IMMUNE SERUMS , *AEDES , PROBES , INFECTIOUS DISEASES , IMMUNITY , MOSQUITO BORNE DISEASES , DENGUE VIRUS , HOSTS(BIOLOGY) , VIRUSES , MEALS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE